Modulation of SERCA2 activity: regulated splicing and interaction with phospholamban.
نویسندگان
چکیده
Ca(2+)-uptake into intracellular stores is mediated by the sarco/endoplasmic reticulum Ca(2+)ATPases (SERCAs). This review deals first with the gene structural and the characterization of the tissue-specific SERCA2 transcript processing. Secondly, the two different protein isoforms and their regulation are described. Finally, this review ends with a discussion on the possible physiological role of the SERCA2 isoform diversity.
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ورودعنوان ژورنال:
- Bioscience reports
دوره 15 5 شماره
صفحات -
تاریخ انتشار 1995